Veda HealthCare
Uttam Nagar, Delhi
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HEPATITIS NEW

Providing you the best range of ledikast, sofokast and velakast with effective & timely delivery.

LEDIKAST

LEDIKAST
  • LEDIKAST
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Approx. Price: Rs 17,000 / PieceGet Latest Price
Product Details:<br /> <table><tr><td>Company</td><td>Aprazer Healthcare</td></tr><tr><td>Dosage Form</td><td>Tablets</td></tr><tr><td>Dose Or Strength (Mg)</td><td>90mg and 400mg</td></tr><tr><td>Form Of Medicines</td><td>Tablets</td></tr><tr><td>Generic</td><td>Ledipasvir and Sofosbuvir</td></tr><tr><td>Manufacturer</td><td>Natco Pharma Limited</td></tr><tr><td>Packaging Size</td><td>28 Tablets</td></tr><tr><td>Packing Size</td><td>28 Tablets</td></tr><tr><td>Power (Mg)</td><td>90mg and 400mg</td></tr></table><br /><p>Each film-coated tablet Contains:</p><p>Ledipasvir 90 mg</p><p>Sofosbuvir 400 mg</p><p>Colors: Yellow oxide of Iron, Titanium Dioxide IP and FD&C Blue#2</p><p>Ledikast is a fixed-dose combination tablet containing ledipasvir and sofosbuvir for oral administration. Ledipasvir is an HCV NS5A inhibitor and sofosbuvir is a nucleotide analog inhibitor of HCV NS5B polymerase.</p><p>Each film-coated tablet contains 90 mg ledipasvir and 400 mg sofosbuvir. The tablet includes the following inactive ingredients: colloidal silicon dioxide, copovidone, croscarmellose sodium, lactose monohydrate, magnesium stearate, and microcrystalline cellulose. The tablet is film-coated with a coating material containing the following inactive ingredients: Yellow Oxide of Iron, polyethylene glycol, polyvinyl alcohol, talc, FD&C Blue #2 and titanium dioxide IP.</p><p>Ledipasvir: The IUPAC name for ledipasvir is Methyl [(2S)-1-{(6S)-6-[5-(9,9-difluoro-7-{2-[(1R,3S,4S)-2-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-2azabicyclo[2.2.1] hept-3-yl]-1H-benzimidazol-6-yl}-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-azaspiro[2.4] hept-5-yl}-3-methyl-1-oxobutan-2-yl]carbamate.</p><p>2.0 CLINICAL PHARMACOLOGY</p><p>2.1 Mechanism of Action</p><p>Ledikast is a fixed-dose combination of ledipasvir and sofosbuvir which are directacting antiviral agents against the hepatitis C virus.</p><p>2.2 Pharmacodynamics</p><p>Cardiac Electrophysiology</p><p>Ledipasvir at a dose of 120 mg twice daily (2.67 times the maximum recommended dosage) and sofosbuvir 400 mg (maximum recommended dosage) and 1200 mg (three times the maximum recommended dosage) does not prolong QTc in clinical trials.</p><p> </p>
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Sofokast

Sofokast
  • Sofokast
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Approx. Price: Rs 4,000 / PieceGet Latest Price
Product Details:
BrandSofokast
CompanyAprazer Healthcare
Dosage Form (If Applicable)Tablets
Dose400 mg
Generic NameSofosbuvir
Packing28 Tablets

The medicinal product “Sofoskast” is treated with a chronic form of Hepatitis C. Complex therapy with the use of this drug and other medications are prescribed for adult patients. The drug also treats patients with HIV and co-infections. The active component of the Sofokast tablets is sofosbuvir. They are coated and contain 400 mg of the basic substance. The package contains 28 tablets.

Indications for use of the drug

The drug “Sofosbuvir 400mg” is prescribed for patients with hepatitis C when the disease has passed into a chronic form. A combined approach is used for the effectiveness of treatment. It is possible to use medicament in cases when the patient has HIV in addition to hepatitis.

Contraindications to taking the drug “Sofosbuvir”

The drug is not used for hypersensitivity to substances that are present in its composition. Despite the fact that the drug does not affect fertility, it is rarely prescribed to women in their reproductive years. The use of the drug during pregnancy and breastfeeding is not recommended, as it can be harmful to the child. When pregnancy occurs, the combination of Sofosbuvir with such drugs as Interferon alfa and Ribavirin may have a negative effect on its course. For this reason, during the period of treatment, the child’s bearing is undesirable. The experiments, during which the drug “buy sofosbuvir online” was tested in animals, showed that this drug has a slightly negative impact on the offspring. Before you start taking it, you should carefully study the instructions for the drug and consult with a specialist.

Side Effect

  • Side effects are fully dependent on those drugs that are used in addition to Sofosbuvir, t. the main component can cause an only headache and mild weakness.
  • We describe the possible negative effects with different combinations of Sofosbuvir in the course of treatment at 12 weeks:
  • Ribavirin, more than 10% of cases. Blood can decrease the concentration of hemoglobin and increase the bilirubin index, insomnia, nausea may occur.
  • Ribavirin, up to 10 %. Anemia, depression, dyspnea, cough, disorders in the digestive tract, hair loss, itching on the skin, cramps, pains in the joints and back and some others.
  • Interferon alfa and Ribavirin, more than 10% of cases. There is anemia, a decrease in the number of platelets and lymphocytes, impaired appetite, dizziness, insomnia, shortness of breath, diarrhea, vomiting, nausea, increased bilirubin, myalgia, joint pain, irritability, rashes and itching on the skin, fever,
  • Interferon alfa and ribavirin, less than 10 %. Depression, anxiety, weight loss, migraine, impaired vision, memory and concentration, constipation, reflux, cramps, back and chest pain, asthenia, hair loss.

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Velakast

Velakast
  • Velakast
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Approx. Price: Rs 12,000 / PieceGet Latest Price
Product Details:
CompanyAprazer Healthcare
Dose100mg-400mg
Dose Or Strength (Mg)100mg and 400mg
Generic NameVelpatasvir and Sofosbuvir
ManufacturerNatco Pharma Limited
Packaging TypeBottles
Packing Size28 Tablets
Strength (mg)100mg and 400mg

VELAKAST TABLETS

VELAKAST is a fixed-dose combination tablet containing sofosbuvir and velpatasvir for oral administration. Sofosbuvir is a nucleotide analog HCV NS5B polymerase inhibitor and velpatasvir is an NS5A inhibitor. Each tablet contains 400 mg sofosbuvir and 100 mg velpatasvir. The tablets include the following inactive ingredients: copovidone, croscarmellose sodium, magnesium stearate, and microcrystalline cellulose. The tablets are film-coated with a coating material containing the following inactive ingredients: Titanium Dioxide IP and Brilliant Blue FCF, polyethylene glycol, polyvinyl alcohol, talc, and titanium dioxide.

Effect of the drug

Thanks to the powerful composition of the drug, Velakast APRAZER HEALTHCARE is widely used to fight the hepatitis C virus of genotypes 1-6. The drug may be given as a monotherapy or for combined treatment with or without cirrhosis. The high effectiveness of the drug against all genotypes of HCV is due to the presence in its composition:

Sofosbuvir: The IUPAC name for sofosbuvir is (S)-Isopropyl 2-((S)-(((2R,3R,4R,5R)-5(2,4-dioxo-3,4-dihydropyrimidin- 1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran- 2yl)methoxy  (phenoxy)phosphorylamino)propanoate. It has a molecular formula of C22H29FN3 O9 P and a molecular weight of 529.45. Sofosbuvir is a white to off-white crystalline solid with a solubility of at least 2 mg/mL across the pH range of 2–7.7 at 37°C and is slightly soluble in water.

Velpatasvir: The IUPAC name for velpatasvir is Methyl {(1R)-2-[(2S,4S)-2-(5-{2[(2S,5S)-1-{(2S)-2-[(methoxycarbonyl) amino]-3-methylbutanoyl}-5-methylpyrrolidin-2-yl]1,11-dihydro[2]benzopyrano[4′,3′:6,7]naphtho[1,2-d]imidazol-9- yl}-1H-imidazol-2-yl)-4(methoxymethyl)pyrrolidin-1-yl]-2-oxo-1-phenylethyl}carbamate. It has a molecular formula of C49H54 N8 O8 and a molecular weight of 883.0. Velpatasvir is practically insoluble (less than 0.1 mg/mL) above pH 5, slightly soluble (3.6 mg/mL) at pH 2, and soluble (greater than 36 mg/mL) at pH 1.2.

Mechanism of Action

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Yogi Sharma (Proprietor)
C-38, Ground Floor, 4th Floor, Milap Nagar Old Pankha Road
Uttam Nagar, Delhi -110059,India



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